PRISM

Before enrollment, every candidate undergoes a structured screening interview covering medical history, current medications, and any known allergic reactions. Screening staff record baseline vital signs including heart rate, blood pressure, and body temperature, and cross-check these against the exclusion criteria defined in section three. Any candidate presenting with an active infection, uncontrolled chronic condition, or pregnancy is deferred from enrollment until the condition resolves or the pregnancy concludes. Screening also includes a review of prior participation in similar studies within the past twelve months, since overlapping enrollment can confound outcome measurements. Staff document the review outcome in the candidate's intake file and forward flagged cases to the supervising clinician for a secondary opinion before any enrollment decision is finalized. A second-tier screening step applies to candidates flagged during intake: an extended panel covering liver function, renal function, and coagulation markers. Results are reviewed within forty-eight hours, and any out-of-range value triggers a consult with the site's principal investigator before the candidate proceeds further. Blood samples are drawn using standard venipuncture technique into three